Viropil Tablet contains Dolutegravir, Lamivudine and Tenofovir Disoproxil Fumarate is an antiretroviral medication used in the management of HIV-1 infection.

Brand Name: Viropil

Composition: Dolutegravir, Lamivudine, Tenofovir Disoproxil Fumarate

Mechanism of Action:

The reverse transcriptase enzyme is inhibited by tenofovir, which stops viral RNA from being converted to DNA and stops the virus from multiplying inside the host cells. By lowering the blood's viral load, this dual action strengthens the immune system and lowers the risk of consequences from HIV.

Uses:

HIV Infection

Dosage and Administration:

One tablet taken once a day, with or without food, is the usual dosage.

Side Effects:

• Fatigue
• Headache
• Nausea
• Vomiting
• Fever
• Cough
• Insomnia
• Liver Function Abnormalities
• Allergic Reactions

Safety Advise:

Kidney  

Monitor kidney function regularly, as Viropil can cause nephrotoxicity. Kindly speak with your healthcare provider.

Liver  

Monitor liver function regularly, as Viropil can cause liver impairement. Kindly speak with your healthcare provider.

Pregnancy  

Viropil should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Viropil while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Alcohol  

Viropil should not be taken with alcohol. Kindly speak with your healthcare provider.

Storage:

Store Viropil Tablet at a temperature between 15°C and 30°C (59°F to 86°F). Keep the tablets in the original packaging to protect them from light and moisture. Keep out of reach of children.

How to use this Medication?

Drink a glass of water along with this prescription. Take it daily at the same time as specified on the prescription label. Consume it with food. Take each dose exactly as directed on the prescription label for the best potential outcome from your therapy. Don't miss any dosages. The virus may become resistant to this and other medications if doses are skipped. Unless instructed otherwise by your care team, continue taking this therapy.

 

Discuss the usage of this drug in children with your care team. For certain illnesses, it can be administered to youngsters as young as 12, although there are safety precautions to take.

References:

1.     Cahn P, Madero JS, Arribas JR, Antinori A, Ortiz R, Clarke AE, Hung CC, Rockstroh JK, Girard PM, Sievers J, Man C. Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2): week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials. The Lancet. 2019 Jan 12;393(10167):143-55.

2.      Scott LJ. Dolutegravir/lamivudine single-tablet regimen: a review in HIV-1 infection. Drugs. 2020 Jan;80(1):61-72.

3.   Venter WD, Sokhela S, Simmons B, Moorhouse M, Fairlie L, Mashabane N, Serenata C, Akpomiemie G, Masenya M, Qavi A, Chandiwana N. Dolutegravir with emtricitabine and tenofovir alafenamide or tenofovir disoproxil fumarate versus efavirenz, emtricitabine, and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection (ADVANCE): week 96 results from a randomised, phase 3, non-inferiority trial. The lancet HIV. 2020 Oct 1;7(10):e666-76.

Disclaimer:

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Marketer details

Name: Emcure Pharmaceuticals Ltd

Address: 255/2, Hinjawadi, Pune - 411057, India

Country of origin: India