Trombonat 25mg Tablet contains Eltrombopag, is used to treat low platelet counts brought on by chronic hepatitis C virus infection or chronic immunological (idiopathic) thrombocytopenic purpura. Additionally, severe aplastic anemia is treated with it. 

Brand Name: Trombonat

Composition: Eltrombopag

Mechanism of Action:

Eltrombopag's mechanism of action is similar to that of thrombopoietin, a natural hormone that stimulates the production of platelets from megakaryocytes in the bone marrow. Eltrombopag increases platelet production by promoting the proliferation and differentiation of megakaryocyte progenitors through the activation of the thrombopoietin receptor.

Uses:

·         Chronic immune thrombocytopenia

·         Thrombocytopenia in Chronic Hepatitis C Patients

·         Aplastic Anemia

Side effects:

·         Nausea

·         Vomiting

·         Fatigue

·         Headache

·         Diarrhea

·         Dizziness

·         Thrombotic events (blood clots)

·         Hepatotoxicity (liver damage)

·         Bone marrow fibrosis

Dosage and Administration:

Trombonat is administered as orally. Depending on the ailment being treated, different amounts are advised; typical dosages range from 25 mg to 75 mg once day, with adjustments made based on response and platelet counts. It should be taken regularly in relation to meals, whether it is taken with or without food.

Safety Advise:

Lungs  

The safety of Trombonat for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Trombonat for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Trombonat for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy   

Trombonat should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Trombonat while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:        

Storage in 30 °C, keep away from children and place away from sun light.

How to use this Medication?

Take this medication orally. Take this medication with a low-calcium meal, on an empty stomach, or at least 30 minutes before or two hours after eating. For two hours before and four hours after taking this medication, stay away from foods high in calcium, antacids, aluminum, calcium, iron, magnesium, selenium, and zinc products. Take your medication on a regular basis. Avoid taking it more frequently than prescribed. Except as directed by your physician, do not discontinue taking.

Contact an emergency department or poison control center right away if you believe you have taken too much of this medication.

References:

1.      Garnock-Jones KP, Keam SJ. Eltrombopag. Drugs. 2009 Mar;69:567-76.

2.    Bussel JB, Cheng G, Saleh MN, Psaila B, Kovaleva L, Meddeb B, Kloczko J, Hassani H, Mayer B, Stone NL, Arning M. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. New England Journal of Medicine. 2007 Nov 29;357(22):2237-47.

3.      Scheinberg P. Activity of eltrombopag in severe aplastic anemia. Blood Advances. 2018 Nov 13;2(21):3054-62.

4.      Bussel JB, Pinheiro MP. Eltrombopag. Hematopoietic Growth Factors in Oncology. 2010 Oct 18:289-303.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India