Torinat 5mg Tablet includes Everolimus, a medication that belongs to the class of drugs known as mTOR inhibitors (mammalian target of rapamycin inhibitors). It is mostly used to treat cancer as well as other illnesses.
Brand Name: Torinat
Composition: Everolimus
Mechanism of Action:
The mTOR pathway, which is essential for cell division, growth, and survival, is inhibited by everolimus. Everolimus inhibits mTOR, which decreases cell division and limits the growth of cancerous cells.
Uses:
- Kidney Cancer
- Neuroendocrine tumors of pancreatic origin
- Hormone receptor-positive breast cancer
- Tuberous Sclerosis Complex
Dosage and Administration:
The typical dosage is 5mg once daily, but it can vary based on the specific condition being treated and the patient's response. Taken orally, with or without food. It is important to take it consistently at the same time each day.
Side Effects:
- Mouth sores
- Nausea
- Diarrhea
- Fatigue
- Rash
- Fever
- Loss of appetite
- Increased risk of infections due to immunosuppression
- Pneumonitis
- Elevated cholesterol and triglycerides
Safety Advise:
Lungs 
There have been reports of lung inflammation in patients taking everolimus. Kindly speak with your Healthcare provider.
Kidney 
Creatinine values may rise after taking everolimus, suggesting possible renal impairment. While receiving treatment, patients should have routine renal function testing. Kindly speak with your Healthcare provider.
Liver 
Use of Torinat 5 Tablet is not recommended in patients with severe liver disease. Kindly speak with your Healthcare provider.
Pregnancy 
Everolimus can cause harm to the fetus, leading to birth defects or fetal death. Kindly speak with your Healthcare provider.
Breast Feeding 
Everolimus is not recommended for breastfeeding mothers, as it can pass into breast milk and may harm the nursing infant. Kindly speak with your Healthcare provider.
Alcohol 
It is unknown if drinking alcohol with taking an Torinat 5 Tablet is safe. Kindly speak with your Healthcare Provider.
Storage:
Store at room temperature, away from moisture and heat. Keep out of reach of children.
How to use this Medication?
Take this medication as directed on the prescription label, orally, along with a full glass of water. Avoid grapefruit juice and do not cut, crush, or chew the tablets. Take them consistently at the same times and discontinue only as directed by your doctor.
Your pharmacist will provide you with a unique MedGuide with every prescription and refill. Every time, make sure to carefully read this information.
Consult your pediatrician about the usage of this medication in young patients. Precautions do apply even though this medication may be administered for some diseases in children as young as one year old.
References:
1. Houghton PJ. Everolimus. Clinical cancer research. 2010 Mar 1;16(5):1368-72.
2. Hasskarl J. Everolimus. Small molecules in oncology. 2018:101-23.
3. Kirchner GI, Meier-Wiedenbach I, Manns MP. Clinical pharmacokinetics of everolimus. Clinical pharmacokinetics. 2004 Feb;43:83-95.
4. Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, Hobday TJ, Okusaka T, Capdevila J, De Vries EG, Tomassetti P. Everolimus for advanced pancreatic neuroendocrine tumors. New England Journal of Medicine. 2011 Feb 10;364(6):514-23.
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Marketer details
Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Country of origin: India