Natzold 5mg Infusion contains Zoledronic acid, are used to treat or prevent osteoporosis caused by steroid usage or menopause, as well as to control elevated calcium levels in cancer patients. 

Brand Name: Natzold

Composition: Zoledronic acid

Mechanism of Action:

Natzold preventing the resorption of bone mediated by osteoclasts, which lowers bone turnover and contributes to bone density maintenance. Because of its great affinity for bone tissue, it can have a long-lasting impact.

Uses: 

·         Osteoporosis

·         Paget's Disease

·         Bone Metastases

·         Malignancy-related hypercalcemia

Side effects:

·         Flu-like symptoms

·         Fever

·         Chills

·         Myalgia

·         Nausea

·         Vomiting

·         Fatigue

·         Hypocalcemia

·         Osteonecrosis of the jaw

Dosage and Administration: 

Usually given intravenously over a period of 15 minutes. Prior to treatment, make sure you are properly hydrated to reduce kidney toxicity.

Safety Advise:

Kidney  

The usage of Natzold 5mg injection in individuals with renal dysfunction may lead to serious effect. Kindly speak with your healthcare provider. 

Liver  

The usage of Natzold 5mg injection in individuals with liver dysfunction may lead to serious effect. Kindly speak with your healthcare provider.

  Pregnancy  

Natzold 5mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. Kindly speak with your healthcare provider.

Breast Feeding  

Natzold 5mg is likely dangerous to use an injection while breast feeding. The medication may damage the unborn child if it enters the breastmilk. Kindly speak with your healthcare provider.

Storage:

Store in a refrigerator (2°C to 8°C). Do not freeze.

How to use this Medication?

This medication is given intravenously. It is administered at a hospital or clinic by a medical professional. Consult your physician regarding this medication's usage in minors. There could be a need for extra caution. 

Contact an emergency department or poison control center right away if you believe you may have taken too much of this medication.

References:

1.     Yuasa T, Kimura S, Ashihara E, Habuchi T, Maekawa T. Zoledronic acid-a multiplicity of anti-cancer action. Current medicinal chemistry. 2007 Aug 1;14(20):2126-35.

2.     Cheer SM, Noble S. Zoledronic acid. Drugs. 2001 May;61:799-805.

3.     Dhillon S. Zoledronic acid (Reclast®, Aclasta®): a review in osteoporosis. Drugs. 2016 Nov;76:1683-97.

4.  Tenta R, Pitulis N, Tiblalexi D, Consoulas C, Katopodis H, Konstantinidou E, Manoussakis M, Kletsas D, Alexis MN, Poyatzi A, Koutsilieris M. Mechanisms of the action of zoledronic acid on human MG-63 osteosarcoma cells. Hormone and metabolic research. 2008 Nov;40(11):737-45.

Disclaimer: 

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India